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Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice

reported a series of alkyl benzoquinones that preferentially inhibit GLS2 rather than GLS1, which function through the specific binding to an allosteric pocket at the C-terminal end of GLS2 monomer (133)

Although the half-life is sometimes quoted as being approximately 7-42 hours, there is actually no fixed half-life

10.1021/jf101084e 29 ClemmonsD

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The resulting sequence file was subjected to SSN analysis using an alignment score of 120 and a minimum and maximum sequence length of 250 and 650 residues in an effort to eliminate truncation artifacts